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Article

Natural single-nucleotide polymorphisms in the 3' region of the HIV-1 pol gene modulate viral replication ability.

Journal of virology - 1 Apr 2014

Nomaguchi Masako, Miyake Ariko, Doi Naoya, Fujiwara Sachi, Miyazaki Yasuyuki, Tsunetsugu-Yokota Yasuko, Yokoyama Masaru, Sato Hironori, Masuda Takao, Adachi Akio

Abstract excerpt

UNLABELLED: We previously showed that prototype macaque-tropic human immunodeficiency virus type 1 (HIV-1) acquired nonsynonymous growth-enhancing mutations within a narrow genomic region during the adaptation process in macaque cells. These adaptive mutations were clustered in the 3' region of the pol gene, encoding a small portion of the C-terminal domain of integrase (IN). Mutations in HIV-1 IN have been...

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Source

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Identifiers

PMID: 24478432
DOI: 10.1128/JVI.01859-13
PMCID: PMC3993728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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