Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suboptimal nucleotides in the infectious, pathogenic simian immunodeficiency virus clone SIVmac239.

Journal of virology - 1 Apr 2001

Alexander L, Denekamp L, Czajak S, Desrosiers R C

Abstract excerpt

We analyzed virus sequences in two monkeys infected with SIVmac239 and two monkeys infected with SHIVnef that maintained high, persisting viral loads. Sequence changes were observed consistently at four loci in all four animals: a single nucleotide change in the Lys-tRNA primer binding site in the 5' long terminal repeat; two nucleotide changes that resulted in two amino acid changes in the pol gene product; and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Products, nef
Share to Gene Products, pol
Share to Gene Products, rev

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Products, tat

Share to nef Gene Products, Human Immunodeficiency Virus

Share to rev Gene Products, Human Immunodeficiency Virus

Share to RNA, Transfer, Lys

Share to tat Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 11264395
DOI: 10.1128/JVI.75.8.4019-4022.2001
PMCID: PMC114897

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suboptimal nucleotides in the infectious, pathogenic simian immunodeficiency virus clone SIVmac239.PMID 11264395Read ↗

The Complete Nucleotide Sequence of a Pathogenic Molecular Clone of Simian Immunodeficiency VirusSemantic proximity Read ↗

Derivation and Characterization of Pathogenic Transmitted/Founder Molecular Clones from Simian Immunodeficiency Virus SIVsmE660 and SIVmac251 following Mucosal Infection.Semantic proximity Read ↗

Large-scale nucleotide optimization of simian immunodeficiency virus reduces its capacity to stimulate type I interferon in vitro.Semantic proximity Read ↗

Genetic and Biological Comparisons of Pathogenic and Nonpathogenic Molecular Clones of Simian Immunodeficiency Virus (SIV <sub>MAC</sub> )Semantic proximity Read ↗

Determinants of Increased Replicative Capacity of Serially Passaged Simian Immunodeficiency Virus with nef Deleted in Rhesus MonkeysSemantic proximity Read ↗

Characterization of molecularly cloned simian-human immunodeficiency viruses causing rapid CD4+ lymphocyte depletion in rhesus monkeys.Semantic proximity Read ↗

Molecularly tagged simian immunodeficiency virus SIVmac239 synthetic swarm for tracking independent infection events.Semantic proximity Read ↗

The genetic fate of molecularly cloned simian immunodeficiency virus in experimentally infected macaques.Semantic proximity Read ↗

Viral outcome of simian-human immunodeficiency virus SHIV-89.6P adapted to cynomolgus monkeys.Semantic proximity Read ↗

Variation of human immunodeficiency virus type-1 reverse transcriptase within the simian immunodeficiency virus genome of RT-SHIV.Semantic proximity Read ↗

Sequence variability of simian immunodeficiency virus in a persistently infected rhesus monkey.Semantic proximity Read ↗

Leader sequences downstream of the primer binding site are important for efficient replication of simian immunodeficiency virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.