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Generation of HIV-1 derivatives that productively infect macaque monkey lymphoid cells

25 Oct 2006

Abstract excerpt

The narrow host range of human immunodeficiency virus type 1 (HIV-1) is caused in part by innate cellular factors such as apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) and TRIM5alpha, which restrict virus replication in monkey cells. Variant HIV-1 molecular clones containing both a 21-nucleotide simian immunodeficiency virus (SIV) Gag CA element, corresponding to the HIV-1...

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PMID: 17065315
DOI: 10.1073/pnas.0608289103

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