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Article

Replication of chimeric human immunodeficiency virus type 1 (HIV-1) containing HIV-2 integrase (IN): naturally selected mutations in IN augment DNA synthesis.

Journal of virology - 1 Oct 2003

Padow Marcus, Lai Lilin, Deivanayagam Champion, DeLucas Lawrence J, Weiss Robert B, Dunn Diane M, Wu Xiaoyun, Kappes John C

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) integrase (IN) protein augments the initiation of reverse transcription. Chimeric HIV-1 containing HIV-2 IN (SG3(IN2)) is severely impaired in virus infectivity and DNA synthesis. To analyze the nature of this defect, we infected T cells with the chimeric SG3(IN2) virus and by continuous passage in cell culture selected for virus with improved replication...

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Share to Chimera
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Complementation Test

Share to HIV Integrase

Share to HIV Reverse Transcriptase

Share to Transcription, Genetic

Share to Virus Replication

Source

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Identifiers

PMID: 14512553
DOI: 10.1128/jvi.77.20.11050-11059.2003
PMCID: PMC224969

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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