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Article

Loss of BRM expression is a frequently observed event in poorly differentiated clear cell renal cell carcinoma.

Histopathology - 1 May 2014

Xia Qiu-Yuan, Rao Qiu, Cheng Liang, Shen Qin, Shi Shan-Shan, Li Li, Liu Biao, Zhang Jin, Wang Yan-Fen, Shi Qun-Li, Wang Jian-Dong, Ma Heng-Hui, Lu Zhen-Feng, Yu Bo, Zhang Ru-Song, Zhou Xiao-Jun

Abstract excerpt

AIMS: The aim of this study was to examine the status of Brahma (BRM), a key SWI/SNF complex subunit, in clear cell renal cell carcinomas (RCCs), and to analyse the histopathology, immunophenotype, molecular features and prognosis of the BRM-negative cases. METHODS AND RESULTS: We identified 19 cases of grade 4 tumours lacking BRM expression among 625 clear cell RCCs. All 19 cases exhibited features of poor...

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PMID: 24471421
DOI: 10.1111/his.12334

Genes

VHL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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