Article
Genetic variation in the prostaglandin E2 pathway is associated with primary graft dysfunction.
American journal of respiratory and critical care medicine - 1 Mar 2014
Diamond Joshua M, Akimova Tatiana, Kazi Altaf, Shah Rupal J, Cantu Edward, Feng Rui, Levine Matthew H, Kawut Steven M, Meyer Nuala J, Lee James C, Hancock Wayne W, Aplenc Richard, Ware Lorraine B, Palmer Scott M, Bhorade Sangeeta, Lama Vibha N, Weinacker Ann, Orens Jonathan, Wille Keith, Crespo Maria, Lederer David J, Arcasoy Selim, Demissie Ejigayehu, Christie Jason D
Abstract excerpt
RATIONALE: Biologic pathways with significant genetic conservation across human populations have been implicated in the pathogenesis of primary graft dysfunction (PGD). The evaluation of the role of recipient genetic variation in PGD has thus far been limited to single, candidate gene analyses. OBJECTIVES: We sought to identify genetic variants in lung transplant recipients that are responsible for increased risk...
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