Variation in PTX3 is associated with primary graft dysfunction after lung transplantation.

doi:10.1164/rccm.201204-0692OC

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Article

Variation in PTX3 is associated with primary graft dysfunction after lung transplantation.

American journal of respiratory and critical care medicine - 15 Sept 2012

Diamond Joshua M, Meyer Nuala J, Feng Rui, Rushefski Melanie, Lederer David J, Kawut Steven M, Lee James C, Cantu Edward, Shah Rupal J, Lama Vibha N, Bhorade Sangeeta, Crespo Maria, Demissie Ejigayehu, Sonett Joshua, Wille Keith, Orens Jonathan, Weinacker Ann, Weill David, Arcasoy Selim, Shah Pali D, Belperio John A, Wilkes David, Ware Lorraine B, Palmer Scott M, Christie Jason D

Abstract excerpt

RATIONALE: Elevated long pentraxin-3 (PTX3) levels are associated with the development of primary graft dysfunction (PGD) after lung transplantation. Abnormalities in innate immunity, mediated by PTX3 release, may play a role in PGD pathogenesis. OBJECTIVES: Our goal was to test whether variants in the gene encoding PTX3 are risk factors for PGD. METHODS: We performed a candidate gene association study in...

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Identifiers

PMID: 22822025
DOI: 10.1164/rccm.201204-0692OC
PMCID: PMC3480532

Genes

PTX3
PGD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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