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Article

Human chondrocytes respond discordantly to the protein encoded by the osteoarthritis susceptibility gene GDF5.

PloS one - 1 Jan 2014

Ratnayake Madhushika, Plöger Frank, Santibanez-Koref Mauro, Loughlin John

Abstract excerpt

A genetic deficit mediated by SNP rs143383 that leads to reduced expression of GDF5 is strongly associated with large-joint osteoarthritis. We speculated that this deficit could be attenuated by the application of exogenous GDF5 protein and as a first step we have assessed what effect such application has on primary osteoarthritis chondrocyte gene expression. Chondrocytes harvested from cartilage of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24466161
DOI: 10.1371/journal.pone.0086590
PMCID: PMC3897745

Genes

GDF5
MMP1
MMP13
TIMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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