Article
A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility.
Human molecular genetics - 15 May 2008
Chapman Kay, Takahashi Atsushi, Meulenbelt Ingrid, Watson Chris, Rodriguez-Lopez Julio, Egli Rainer, Tsezou Aspasia, Malizos Konstantinos N, Kloppenburg Margreet, Shi Dongquan, Southam Lorraine, van der Breggen Ruud, Donn Rachelle, Qin Jianghui, Doherty Michael, Slagboom P Eline, Wallis Gillian, Kamatani Naoyuki, Jiang Qing, Gonzalez Antonio, Loughlin John, Ikegawa Shiro
Abstract excerpt
We have performed a meta-analysis combining data for more than 11,000 individuals. It provides compelling evidence for a positive association between a functional single-nucleotide polymorphism (SNP) in the 5'-UTR of GDF5 (+104T/C; rs143383) and osteoarthritis (OA) in European and Asian populations. This SNP has recently been reported to be associated with OA in Japanese and Han Chinese populations. Attempts to...
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