The GDF-5 mutant M1673 exerts robust anabolic and anti-catabolic effects in chondrocytes.

doi:10.1111/jcmm.15149

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Article

The GDF-5 mutant M1673 exerts robust anabolic and anti-catabolic effects in chondrocytes.

Journal of cellular and molecular medicine - 1 Jul 2020

Mang Tanja, Kleinschmidt-Dörr Kerstin, Ploeger Frank, Lindemann Sven, Gigout Anne

Abstract excerpt

The growth and differentiation factor 5 (GDF-5) is known to play a key role in cartilage morphogenesis and homeostasis, and a single-nucleotide polymorphism in its promoter sequence was found to be associated with osteoarthritis (OA). In addition, GDF-5 was shown to promote extracellular matrix (ECM) production in healthy chondrocytes, to stimulate chondrogenesis of mesenchymal stem cells (MSCs) and to protect...

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PMID: 32497388
DOI: 10.1111/jcmm.15149
PMCID: PMC7339174

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