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Article

A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis.

Nature genetics - 1 Apr 2007

Miyamoto Yoshinari, Mabuchi Akihiko, Shi Dongquan, Kubo Toshikazu, Takatori Yoshio, Saito Susumu, Fujioka Mikihiro, Sudo Akihiro, Uchida Atsumasa, Yamamoto Seizo, Ozaki Koichi, Takigawa Masaharu, Tanaka Toshihiro, Nakamura Yusuke, Jiang Qing, Ikegawa Shiro

Abstract excerpt

Osteoarthritis (MIM 165720), characterized by degeneration of articular cartilage, is the most common form of human arthritis and a major concern for aging societies worldwide. Epidemiological and genetic studies have shown that osteoarthritis is a polygenic disease. Here, we report that the gene...

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Source

Identifiers

PMID: 17384641
DOI: 10.1038/2005

Genes

GDF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17384641-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis.PMID 17384641Read ↗

An SNP in the 5'-UTR of GDF5 is associated with osteoarthritis susceptibility in Europeans and with in vivo differences in allelic expression in articular cartilage.Semantic proximity Read ↗

Polymorphisms in the Growth Differentiation Factor 5 (GDF 5) Gene in Knee Osteoarthritis.Semantic proximity Read ↗

Association between the +104T/C polymorphism in the 5'UTR of GDF5 and susceptibility to knee osteoarthritis: a meta-analysis.Semantic proximity Read ↗

The growth differentiation factor 5 (GDF5) core promoter polymorphism is not associated with knee osteoarthritis in the Greek population.Semantic proximity Read ↗

The GDF5 rs143383 polymorphism is associated with osteoarthritis of the knee with genome-wide statistical significance.Semantic proximity Read ↗

Rs143383 in the growth differentiation factor 5 (GDF5) gene significantly associated with osteoarthritis (OA)-a comprehensive meta-analysis.Semantic proximity Read ↗

A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility.Semantic proximity Read ↗

A comprehensive meta-analysis of association between genetic variants of GDF5 and osteoarthritis of the knee, hip and hand.Semantic proximity Read ↗

A rare variant in the osteoarthritis-associated locus GDF5 is functional and reveals a site that can be manipulated to modulate GDF5 expression.Semantic proximity Read ↗

Is GDF5 gene promoter polymorphism +104T/C associated with osteoarthritis in the Eastern of Turkey population?Semantic proximity Read ↗

Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism.Semantic proximity Read ↗

Association between GDF5 rs143383 polymorphism and knee osteoarthritis: an updated meta-analysis based on 23,995 subjects.Semantic proximity Read ↗

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