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KRAS phosphorylation regulates cell polarization and tumorigenic properties in colorectal cancer.

Oncogene - 1 Sept 2021

Cabot Débora, Brun Sònia, Paco Noelia, Ginesta Mireia M, Gendrau-Sanclemente Núria, Abuasaker Baraa, Ruiz-Fariña Triana, Barceló Carles, Cuatrecasas Miriam, Bosch Marta, Rentero Carles, Pons Gabriel, Estanyol Josep M, Capellà Gabriel, Jaumot Montserrat, Agell Neus

Abstract excerpt

Oncogenic mutations of KRAS are found in the most aggressive human tumors, including colorectal cancer. It has been suggested that oncogenic KRAS phosphorylation at Ser181 modulates its activity and favors cell transformation. Using nonphosphorylatable (S181A), phosphomimetic (S181D), and phospho-/dephosphorylatable (S181) oncogenic KRAS mutants, we analyzed the role of this phosphorylation to the maintenance of...

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PMID: 34333552
DOI: 10.1038/s41388-021-01967-3

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