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Rhomboid domain containing 1 promotes colorectal cancer growth through activation of the EGFR signalling pathway

24 Aug 2015

Abstract excerpt

Rhomboid proteins perform a wide range of important functions in a variety of organisms. Recent studies have revealed that rhomboid proteins are involved in human cancer progression; however, the underlying molecular mechanism remains largely unclear. Here we show that RHBDD1, a rhomboid intramembrane serine protease, is highly expressed and closely associated with survival in patients with colorectal cancer. We...

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PMID: 26300397
DOI: 10.1038/ncomms9022

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