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Article

RasGRP1 transgenic mice develop cutaneous squamous cell carcinomas in response to skin wounding: potential role of granulocyte colony-stimulating factor.

The American journal of pathology - 1 Jul 2009

Diez Federico R, Garrido Ann A, Sharma Amrish, Luke Courtney T, Stone James C, Dower Nancy A, Cline J Mark, Lorenzo Patricia S

Abstract excerpt

Models of epidermal carcinogenesis have demonstrated that Ras is a critical molecule involved in tumor initiation and progression. Previously, we have shown that RasGRP1 increases the susceptibility of mice to skin tumorigenesis when overexpressed in the epidermis by a transgenic approach, related to its ability to activate Ras. Moreover, RasGRP1 transgenic mice develop spontaneous papillomas and cutaneous...

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Identifiers

PMID: 19497993
DOI: 10.2353/ajpath.2009.090036
PMCID: PMC2708824

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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