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Article

Deregulated expression of RasGRP1 initiates thymic lymphomagenesis independently of T-cell receptors.

Oncogene - 14 Apr 2005

Klinger Mark B, Guilbault Benoit, Goulding Rebecca E, Kay Robert J

Abstract excerpt

RasGRP1 is a Ras-specific exchange factor, which is activated by T-cell receptor (TCR) and promotes TCR-dependent positive selection of thymocytes. RasGRP1 is highly expressed on most T lymphocytic leukemias and is a common site of proviral insertion in retrovirus-induced murine T-cell lymphomas....

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Source

Identifiers

PMID: 15829980
DOI: 10.1038/sj.onc.1208334

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15829980-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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