Epidermal hyperplasia induced by Raf-MAPK signaling requires Stat3 activation.

doi:10.1016/j.jdermsci.2013.06.007

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Article

Epidermal hyperplasia induced by Raf-MAPK signaling requires Stat3 activation.

Journal of dermatological science - 1 Nov 2013

Tarutani Masahito, Nakajima Kimiko, Takaishi Mikiro, Ohko Kentaro, Sano Shigetoshi

Abstract excerpt

BACKGROUND: Raf is one of the downstream effectors of Ras GTPases, and plays a key role in regulating cell proliferation and differentiation through the activation of MAPK. We have previously demonstrated that temporal induction of Raf in the epidermis of K14-Raf:ER transgenic mice results in epidermal hyperplasia resembling squamous cell carcinoma and psoriasis. It has been demonstrated that epidermal Stat3...

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Identifiers

PMID: 23870655
DOI: 10.1016/j.jdermsci.2013.06.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.