Article
Adiposity as a cause of cardiovascular disease: a Mendelian randomization study.
International journal of epidemiology - 1 Apr 2015
Hägg Sara, Fall Tove, Ploner Alexander, Mägi Reedik, Fischer Krista, Draisma Harmen H M, Kals Mart, de Vries Paul S, Dehghan Abbas, Willems Sara M, Sarin Antti-Pekka, Kristiansson Kati, Nuotio Marja-Liisa, Havulinna Aki S, de Bruijn Renée F A G, Ikram M Arfan, Kuningas Maris, Stricker Bruno H, Franco Oscar H, Benyamin Beben, Gieger Christian, Hall Alistair S, Huikari Ville, Jula Antti, Järvelin Marjo-Riitta, Kaakinen Marika, Kaprio Jaakko, Kobl Michael, Mangino Massimo, Nelson Christopher P, Palotie Aarno, Samani Nilesh J, Spector Tim D, Strachan David P, Tobin Martin D, Whitfield John B, Uitterlinden André G, Salomaa Veikko, Syvänen Ann-Christine, Kuulasmaa Kari, Magnusson Patrik K, Esko Tõnu, Hofman Albert, de Geus Eco J C, Lind Lars, Giedraitis Vilmantas, Perola Markus, Evans Alun, Ferrières Jean, Virtamo Jarmo, Kee Frank, Tregouet David-Alexandre, Arveiler Dominique, Amouyel Philippe, Gianfagna Francesco, Brambilla Paolo, Ripatti Samuli, van Duijn Cornelia M, Metspalu Andres, Prokopenko Inga, McCarthy Mark I, Pedersen Nancy L, Ingelsson Erik
Abstract excerpt
BACKGROUND: Adiposity, as indicated by body mass index (BMI), has been associated with risk of cardiovascular diseases in epidemiological studies. We aimed to investigate if these associations are causal, using Mendelian randomization (MR) methods. METHODS: The associations of BMI with cardiovascular outcomes [coronary heart disease (CHD), heart failure and ischaemic stroke], and associations of a genetic score...
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