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The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: A two-step, two-sample Mendelian randomization study

2017-03-19

Abstract excerpt

<h4>Background</h4> The extent to which effects of BMI on coronary heart disease (CHD) are mediated by gylcaemic and lipid risk factors is unclear. <h4>Methods</h4> We used two-sample Mendelian randomization to determine the causal effect of: (i) BMI on CHD (60,801 cases; 123, 504 controls), type 2 diabetes (T2DM; 34,840 cases; 114,981 controls), fasting glucose (n=46,186), insulin (n=38,238), HbA 1c (n=46,368)...

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Literature Corpus work
0494e795-2398-5162-b5ba-231c0116169b
DOI
10.1101/118133
Open publication

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The role of glycaemic and lipid risk factors in mediating the effect of BMI on coronary heart disease: A two-step, two-sample Mendelian randomization studyDOI 10.1101/118133
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