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Article

Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies.

BMC medicine - 15 Dec 2021

Larsson Susanna C, Burgess Stephen

Abstract excerpt

BACKGROUND: Obesity is a worldwide epidemic that has been associated with a plurality of diseases in observational studies. The aim of this study was to summarize the evidence from Mendelian randomization (MR) studies of the association between body mass index (BMI) and chronic diseases. METHODS: PubMed and Embase were searched for MR studies on adult BMI in relation to major chronic diseases, including diabetes...

Topics

Adiposity
Adult
Body Mass Index
Diabetes Mellitus, Type 2
Female
Genome-Wide Association Study
Humans
Male
Mendelian Randomization Analysis
Multiple Chronic Conditions
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34906131
DOI: 10.1186/s12916-021-02188-x
PMCID: PMC8672504

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