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Association of Body Mass Index With Cardiometabolic Disease in the UK Biobank: A Mendelian Randomization Study.

JAMA cardiology - 1 Aug 2017

Lyall Donald M, Celis-Morales Carlos, Ward Joey, Iliodromiti Stamatina, Anderson Jana J, Gill Jason M R, Smith Daniel J, Ntuk Uduakobong Efanga, Mackay Daniel F, Holmes Michael V, Sattar Naveed, Pell Jill P

Abstract excerpt

Importance: Higher body mass index (BMI) is a risk factor for cardiometabolic disease; however, the underlying causal associations remain unclear. Objectives: To use UK Biobank data to report causal estimates of the association between BMI and cardiometabolic disease outcomes and traits, such as pulse rate, using mendelian randomization. Design, Setting, and Participants: Cross-sectional baseline data from a...

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PMID: 28678979
DOI: 10.1001/jamacardio.2016.5804
PMCID: PMC5710596

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