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Isocitrate Dehydrogenase Mutations in Glioma: From Basic Discovery to Therapeutics Development

12 Jun 2019

Abstract excerpt

Isocitrate dehydrogenase (IDH) is a key rate-limiting enzyme in the Krebs cycle that plays an important role in energy metabolism. In recent years, it has been found that IDH mutations are closely related to the occurrence and development of glioma, and it is a notable potential therapeutic target. First, IDH mutations can produce high levels of 2-hydroxyglutaric acid (2-HG), thereby inhibiting glioma stem cell...

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Identifiers

PMID: 31263678
DOI: 10.3389/fonc.2019.00506

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