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IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis

11 Apr 2017

Abstract excerpt

BACKGROUND: Gastric cancer (GC) is one of the frequent causes of cancer-related death in eastern Asian population. IGF2BP2 lists in the top rank up-regulated genes in GC, but its functional role is unclear. METHOD: The expression of IGF2BP3 in GC cell lines and primary samples was examined by qRT-PCR and Western blot. The biological role of IGF2BP3 was revealed by a series of functional in vitro studies. Its...

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PMID: 28399871
DOI: 10.1186/s12943-017-0647-2

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