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Article

Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway.

The Journal of biological chemistry - 16 Sept 2011

Hodson Charlotte, Cole Ambrose R, Lewis Laurence P C, Miles Jennifer A, Purkiss Andrew, Walden Helen

Abstract excerpt

The Fanconi anemia (FA) pathway is essential for the repair of DNA interstrand cross-links. At the heart of this pathway is the monoubiquitination of the FANCI-FANCD2 (ID) complex by the multiprotein "core complex" containing the E3 ubiquitin ligase FANCL. Vertebrate organisms have the eight-protein core complex, whereas invertebrates apparently do not. We report here the structure of the central domain of human...

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Source

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Identifiers

PMID: 21775430
DOI: 10.1074/jbc.M111.244632
PMCID: PMC3173227

Genes

FANCL
FANCD2
FANCI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway.PMID 21775430Read ↗

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