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Article

Evolutionary history expands the range of signaling interactions in hybrid multikinase networks.

Scientific reports - 3 Jun 2021

Ortet Philippe, Fochesato Sylvain, Bitbol Anne-Florence, Whitworth David E, Lalaouna David, Santaella Catherine, Heulin Thierry, Achouak Wafa, Barakat Mohamed

Abstract excerpt

Two-component systems (TCSs) are ubiquitous signaling pathways, typically comprising a sensory histidine kinase (HK) and a response regulator, which communicate via intermolecular kinase-to-receiver domain phosphotransfer. Hybrid HKs constitute non-canonical TCS signaling pathways, with transmitter and receiver domains within a single protein communicating via intramolecular phosphotransfer. Here, we report how...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34083699
DOI: 10.1038/s41598-021-91260-w
PMCID: PMC8175716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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