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Article

Epigenetic reprogramming modulates malignant properties of human liver cancer

21 Jan 2014

Abstract excerpt

UNLABELLED: Reversal of DNA hypermethylation and associated gene silencing is an emerging cancer therapy approach. Here we addressed the impact of epigenetic alterations and cellular context on functional and transcriptional reprogramming of hepatocellular carcinoma (HCC) cells. Our strategy employed a 3-day treatment of established and primary human HCC-derived cell lines grown as a monolayer at various cell...

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PMID: 24449497
DOI: 10.1002/hep.27026

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