The miR‐200b–ZEB1 circuit regulates diverse stemness of human hepatocellular carcinoma

Abstract excerpt

Accumulating evidence suggests that human hepatocellular carcinoma (HCC) can be derived from cancer stem cells (CSCs), which contribute to tumor initiation, metastasis, chemoresistance, and recurrence. A great variety of HCC CSCs resulting in diverse clinical manifestations have been reported. However, how CSC diversity is regulated and generated remains unclear. Here we report that the miR‐200b–ZEB1 circuit is...

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