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Article

WM130 preferentially inhibits hepatic cancer stem-like cells by suppressing AKT/GSK3β/β-catenin signaling pathway.

Oncotarget - 29 Nov 2016

Ni Chen-Xu, Qi Yang, Zhang Jin, Liu Ying, Xu Wei-Heng, Xu Jing, Hu Hong-Gang, Wu Qiu-Ye, Wang Yan, Zhang Jun-Ping

Abstract excerpt

The eradication of cancer stem cells (CSCs) is significant for cancer therapy and prevention. In this study, we evaluated WM130, a novel derivative of matrine, for its effect on CSCs using human hepatocellular carcinoma (HCC) cell lines, their sphere cells, and sorted EpCAM+ cells. We revealed that WM130 could not only inhibit proliferation and colony formation of HCC cells, but also suppress the expression of...

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Identifiers

PMID: 27783993
DOI: 10.18632/oncotarget.12822
PMCID: PMC5346734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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