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Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways

26 May 2011

Abstract excerpt

UNLABELLED: Epigenetic mechanisms play critical roles in stem cell biology by maintaining pluripotency of stem cells and promoting differentiation of more mature derivatives. If similar mechanisms are relevant for the cancer stem cell (CSC) model, then epigenetic modulation might enrich the CSC population, thereby facilitating CSC isolation and rigorous evaluation. To test this hypothesis, primary human cancer...

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PMID: 21618577
DOI: 10.1002/hep.24454

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