Article

Coordinated activation of DNMT3a and TET2 in cancer stem cell-like cells initiates and sustains drug resistance in hepatocellular carcinoma

2022-03-30

Abstract excerpt

<h4>Background: </h4> Resistance to targeted therapies represents a major hurdle to successfully treat hepatocellular carcinoma (HCC). While epigenetic abnormalities are critical determinants of HCC relapse and therapeutic resistance, the underlying mechanisms are poorly understood. We aimed to address whether and how dysregulated epigenetic regulators have regulatory and functional communications in establishing...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a7041ef8-216b-5f98-a6dd-f225efcd57c4
DOI: 10.21203/rs.3.rs-1432174/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Coordinated activation of DNMT3a and TET2 in cancer stem cell-like cells initiates and sustains drug resistance in hepatocellular carcinomaDOI 10.21203/rs.3.rs-1432174/v2Read

DNA methylation-driven EMT is a common mechanism of resistance to various therapeutic agents in cancerSemantic proximity Read

Epigenetic regulation of DNA repair gene program by Hippo/YAP1-TET1 axis mediates sorafenib resistance in HCCSemantic proximity Read

Cancer stem cell-mediated therapeutic resistance in hepatocellular carcinomaSemantic proximity Read

Human menstrual blood-derived stem cells reverse sorafenib resistance in hepatocellular carcinoma cells through the hyperactivation of mitophagySemantic proximity Read

HBx Facilitates Drug Resistance in Hepatocellular Carcinoma via CD133-regulated Self-renewal of Liver Cancer Stem CellsSemantic proximity Read

A Three‐Pronged Epigenetic Approach to the Treatment of Hepatocellular CarcinomaSemantic proximity Read

The paradigm of drug resistance in cancer: an epigenetic perspectiveSemantic proximity Read

Acquired Resistance to Antiangiogenic Therapies in Hepatocellular Carcinoma Is Mediated by Yes‐Associated Protein 1 Activation and Transient Expansion of Stem‐Like Cancer CellsSemantic proximity Read

Decitabine regulates the resistance of Hep3B to sorafenib through demethylationSemantic proximity Read

Inhibition of DNMT3B expression in activated hepatic stellate cells overcomes chemoresistance in the tumor microenvironment of hepatocellular carcinomaSemantic proximity Read

Impact of tumor suppressor genes inactivation on the multidrug resistance phenotype of hepatocellular carcinoma cells.Semantic proximity Read

Decoding the Complexity of Hepatocellular Carcinoma: Clinical Challenges and Targeting HuR as a Novel Therapeutic StrategySemantic proximity Read