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FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML

17 Feb 2020

Abstract excerpt

FOXM1, a known transcription factor, promotes cell proliferation in a variety of cancer cells. Here we show that Foxm1 is required for survival, quiescence and self-renewal of MLL-AF9 (MA9)-transformed leukemia stem cells (LSCs) in vivo. Mechanistically, Foxm1 upregulation activates the Wnt/β-catenin signaling pathways by directly binding to β-catenin and stabilizing β-catenin protein through inhibiting its...

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PMID: 32066721
DOI: 10.1038/s41467-020-14590-9

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