Article
Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in acute myeloid leukemia.
Molecular cancer - 16 Oct 2009
Röhrs Sonja, Dirks Wilhelm G, Meyer Claus, Marschalek Rolf, Scherr Michaela, Slany Robert, Wallace Andrew, Drexler Hans G, Quentmeier Hilmar
Abstract excerpt
BACKGROUND: Translocations of the Mixed Lineage Leukemia (MLL) gene occur in a subset (5%) of acute myeloid leukemias (AML), and in mixed phenotype acute leukemias in infancy - a disease with extremely poor prognosis. Animal model systems show that MLL gain of function mutations may contribute to leukemogenesis. Wild-type (wt) MLL possesses histone methyltransferase activity and functions at the level of...
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