Article
Recombinant human monoclonal antibodies against different conformational epitopes of the E2 envelope glycoprotein of hepatitis C virus that inhibit its interaction with CD81.
The Journal of general virology - 1 Oct 2000
Allander Tobias, Drakenberg Katarina, Beyene Aster, Rosa Domenico, Abrignani Sergio, Houghton Michael, Widell Anders, Grillner Lena, Persson Mats A A
Abstract excerpt
The antibody response to the envelope proteins of hepatitis C virus (HCV) may play an important role in controlling the infection. To allow molecular analyses of protective antibodies, we isolated human monoclonal antibodies to the E2 envelope glycoprotein of HCV from a combinatorial Fab library established from bone marrow of a chronically HCV-infected patient. Anti-E2 reactive clones were selected using...
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