Article
Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene.
Annals of the rheumatic diseases - 1 Mar 2015
Gazal Steven, Sacre Karim, Allanore Yannick, Teruel Maria, Goodall Alison H, Tohma Shigeto, Alfredsson Lars, Okada Yukinori, Xie Gang, Constantin Arnaud, Balsa Alejandro, Kawasaki Aya, Nicaise Pascale, Amos Christopher, Rodriguez-Rodriguez Luis, Chiocchia Gilles, Boileau Catherine, Zhang Jinyi, Vittecoq Olivier, Barnetche Thomas, Gonzalez Gay Miguel A, Furukawa Hiroshi, Cantagrel Alain, Le Loët Xavier, Sumida Takayuki, Hurtado-Nedelec Margarita, Richez Christophe, Chollet-Martin Sylvie, Schaeverbeke Thierry, Combe Bernard, Khoryati Liliane, Coustet Baptiste, El-Benna Jammel, Siminovitch Katherine, Plenge Robert, Padyukov Leonid, Martin Javier, Tsuchiya Naoyuki, Dieudé Philippe
Abstract excerpt
OBJECTIVE: To evaluate the contribution of the SPP1 rs11439060 and rs9138 polymorphisms, previously reported as autoimmune risk variants, in the rheumatoid arthritis (RA) genetic background according to anti-citrullinated protein antibodies (ACPAs) status of RA individuals. METHODS: We analysed a total of 11,715 RA cases and 26,493 controls from nine independent cohorts; all individuals were genotyped or had...
Read the complete abstract on PubMed