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Molecular signatures and new candidates to target the pathogenesis of rheumatoid arthritis

22 Sept 2010

Abstract excerpt

Rheumatoid arthritis (RA) is a chronic, inflammatory joint disease of unknown etiology and pronounced interpatient heterogeneity. To characterize RA at the molecular level and to uncover pathomechanisms, we performed genome-wide gene expression analysis. We identified a set of 1,054 genes significantly deregulated in pair-wise comparisons between RA and osteoarthritis (OA) patients, RA and normal donors (ND), or...

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PMID: 20858714
DOI: 10.1152/physiolgenomics.00004.2010

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