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Decoding SPP1 regulation: Genetic and nongenetic insights into its role in disease progression

8 Apr 2025

Abstract excerpt

Secreted phosphoprotein 1 (SPP1), also known as osteopontin, is a multifunctional glycoprotein that plays a critical role in various physiological processes, including cell adhesion, chemotaxis, immune regulation, and tissue remodeling. Originally identified as a key component of the bone matrix, SPP1 is now recognized for its broad involvement in numerous tissues and significant impact on both normal physiology...

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PMID: 40210132
DOI: 10.1016/j.mocell.2025.100215

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