Article
Sequence variants of the secreted phosphoprotein 1 gene are associated with total serum immunoglobulin E levels in a Japanese population.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Feb 2006
Tanino Y, Hizawa N, Konno S, Fukui Y, Takahashi D, Maeda Y, Huang S K, Nishimura M
Abstract excerpt
BACKGROUND: Secreted phosphoprotein 1 (SPP1) is a cytokine with pleiotrophic immunological activities, including activation of macrophage chemotaxis and T-helper type 1 (Th1) immune responses. SPP1 gene polymorphisms have been shown to be associated with several immune inflammatory diseases including multiple sclerosis (MS), which is characterized by fewer allergic symptoms and lower numbers of allergen...
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