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Article

Osteopontin and systemic lupus erythematosus association: a probable gene-gender interaction.

PloS one - 12 Mar 2008

Han Shizhong, Guthridge Joel M, Harley Isaac T W, Sestak Andrea L, Kim-Howard Xana, Kaufman Kenneth M, Namjou Bahram, Deshmukh Harshal, Bruner Gail, Espinoza Luis R, Gilkeson Gary S, Harley John B, James Judith A, Nath Swapan K

Abstract excerpt

Osteopontin (SPP1) is an important bone matrix mediator found to have key roles in inflammation and immunity. SPP1 genetic polymorphisms and increased osteopontin protein levels have been reported to be associated with SLE in small patient collections. The present study evaluates association between SPP1 polymorphisms and SLE in a large cohort of 1141 unrelated SLE patients [707 European-American (EA) and 434...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18335026
DOI: 10.1371/journal.pone.0001757
PMCID: PMC2258418

Genes

SPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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