Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An osteopontin (SPP1) polymorphism is associated with systemic lupus erythematosus.

Human mutation - 1 Apr 2002

Forton A C, Petri M A, Goldman D, Sullivan K E

Abstract excerpt

Osteopontin (SPP1) is a soluble ligand with pleomorphic immunologic activities including activation of macrophage chemotaxis, promotion of Th1 responses, and activation of B1 B cells. It has been implicated in the development of murine lupus and is overexpressed in humans with systemic lupus erythematosus (SLE). We examined a polymorphism of osteopontin for an association with lupus in humans in an effort to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chi-Square Distribution
Share to Gene Frequency
Share to Lupus Erythematosus, Systemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Opportunistic Infections

Share to Osteopontin

Share to Renal Insufficiency

Share to Sialoglycoproteins

Share to White People

Source

Identifiers

PMID: 11933203
DOI: 10.1002/humu.9025

Genes

SPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An osteopontin (SPP1) polymorphism is associated with systemic lupus erythematosus.PMID 11933203Read ↗

Osteopontin and systemic lupus erythematosus association: a probable gene-gender interaction.Semantic proximity Read ↗

Association of the rs1126616 and rs9138 Variants in the SPP1 Gene among Mexican Patients with Systemic Lupus Erythematosus and Lupus Nephritis.Semantic proximity Read ↗

Correlation between circulating osteopontin level in systemic lupus erythematosus and disease activity and associations between osteopontin polymorphisms and disease susceptibility: A meta-analysis.Semantic proximity Read ↗

Associations Between Osteopontin Variants and Systemic Lupus Erythematosus: A Meta-Analysis.Semantic proximity Read ↗

Osteopontin alleles are associated with clinical characteristics in systemic lupus erythematosus.Semantic proximity Read ↗

Decoding SPP1 regulation: Genetic and nongenetic insights into its role in disease progressionSemantic proximity Read ↗

Osteopontin in Immune-mediated DiseasesSemantic proximity Read ↗

Genetics of osteonecrosis in children and adults with systemic lupus erythematosus.Semantic proximity Read ↗

Bioinformatic Analysis of SNVS of the SPP1 Gene and the Role of Testicular Disease in Systemic Lupus ErythematosusSemantic proximity Read ↗

Two single-nucleotide polymorphisms in the 5' and 3' ends of the osteopontin gene contribute to susceptibility to systemic lupus erythematosus.Semantic proximity Read ↗

Association between Staphylococcus aureus nasal carriage and disease phenotype in patients affected by systemic lupus erythematosus.Semantic proximity Read ↗

Clinical and genetic risk factors for pneumonia in systemic lupus erythematosus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.