Article
Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array.
BMC genomics - 22 Jan 2014
Naeem Haroon, Wong Nicholas C, Chatterton Zac, Hong Matthew K H, Pedersen John S, Corcoran Niall M, Hovens Christopher M, Macintyre Geoff
Abstract excerpt
BACKGROUND: The Illumina HumanMethylation450 BeadChip (HM450K) measures the DNA methylation of 485,512 CpGs in the human genome. The technology relies on hybridization of genomic fragments to probes on the chip. However, certain genomic factors may compromise the ability to measure methylation using the array such as single nucleotide polymorphisms (SNPs), small insertions and deletions (INDELs), repetitive DNA,...
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