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Genome-wide DNA methylation detection by MethylCap-seq and Infinium HumanMethylation450 BeadChips: an independent large-scale comparison.

Scientific reports - 20 Oct 2015

De Meyer Tim, Bady Pierre, Trooskens Geert, Kurscheid Sebastian, Bloch Jocelyne, Kros Johan M, Hainfellner Johannes A, Stupp Roger, Delorenzi Mauro, Hegi Monika E, Van Criekinge Wim

Abstract excerpt

Two cost-efficient genome-scale methodologies to assess DNA-methylation are MethylCap-seq and Illumina's Infinium HumanMethylation450 BeadChips (HM450). Objective information regarding the best-suited methodology for a specific research question is scant. Therefore, we performed a large-scale evaluation on a set of 70 brain tissue samples, i.e. 65 glioblastoma and 5 non-tumoral tissues. As MethylCap-seq coverages...

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PMID: 26482909
DOI: 10.1038/srep15375
PMCID: PMC4612737

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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