Article
T-cell prolymphocytic leukaemia: antigen receptor gene rearrangement and a novel mode of MTCP1 B1 activation.
British journal of haematology - 1 Sept 2000
De Schouwer P J, Dyer M J, Brito-Babapulle V B, Matutes E, Catovsky D, Yuille M R
Abstract excerpt
T-cell prolymphocytic leukaemia (T-PLL) is a sporadic, mature T-cell disorder in which there is usually an aberrant T-cell receptor alpha (TCRA) rearrangement that activates the TCL1 or MTCP1-B1 oncogenes. As mutations of the Ataxia Telangiectasia (A-T) gene, ATM, are frequent in T-PLL and as ATM seems to act as a tumour suppressor through a mechanism involving V(D)J recombination, we examined V(D)J recombination...
Topics
- Alleles
- Base Sequence
- Blotting, Southern
- Chromosomes, Human, Pair 7
- Cytogenetic Analysis
- Gene Deletion
- Gene Rearrangement, T-Lymphocyte
- Humans
- Immunophenotyping
- Leukemia, Prolymphocytic
- Leukemia, T-Cell
- Molecular Sequence Data
- Polymerase Chain Reaction