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Article

Genes encoding members of the JAK-STAT pathway or epigenetic regulators are recurrently mutated in T-cell prolymphocytic leukaemia.

British journal of haematology - 1 Apr 2016

López Cristina, Bergmann Anke K, Paul Ulrike, Murga Penas Eva M, Nagel Inga, Betts Matthew J, Johansson Patricia, Ritgen Matthias, Baumann Tycho, Aymerich Marta, Jayne Sandrine, Russell Robert B, Campo Elias, Dyer Martin J S, Dürig Jan, Siebert Reiner

Abstract excerpt

T-cell prolymphocytic leukaemia (T-PLL) is an aggressive leukaemia. The primary genetic alteration in T-PLL are the inv(14)(q11q32)/t(14;14)(q11;q32) leading to TRD/TRA-TCL1A fusion, or the t(X;14)(q28;q11) associated with TRD/TRA-MTCP1 fusion. However, additional cooperating abnormalities are necessary for emergence of the full neoplastic phenotype. Though the pattern of secondary chromosomal aberrations is...

Topics

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Biomarkers, Tumor
Epigenesis, Genetic
Janus Kinase 3
Proto-Oncogene Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repressor Proteins

rhoA GTP-Binding Protein

STAT5 Transcription Factor

Source

Identifiers

PMID: 26917488
DOI: 10.1111/bjh.13952

Genes

JAK3
TRA
TRD
BCOR
MTCP1
RHOA
TET2

Provenance

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