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Article

Association of TLR7 and TLR9 genes polymorphisms in Egyptian patients with systemic lupus erythematosus

1 Nov 2022

Abstract excerpt

Introduction: Systemic lupus erythematosus (SLE) is a chronic, inflammatory, multiorgan, systemic autoimmune disease. It is characterized by the high production of autoantibodies against nuclear compounds. TLRs (toll-like receptors 7/9) are pattern-recognition receptors that recognize nucleic acids and induce proinflammatory responses by activating NF-kB and producing type I interferon, which play a role in...

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PMID: 36439744
DOI: 10.1016/j.heliyon.2022.e11680

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