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Article

TLR7/8/9 polymorphisms and their associations in systemic lupus erythematosus patients from southern Brazil.

Lupus - 1 Mar 2012

dos Santos B P, Valverde J V, Rohr P, Monticielo O A, Brenol J C T, Xavier R M, Chies J A B

Abstract excerpt

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease and can affect several organs and systems. It is characterized by high production of autoantibodies against nuclear compounds. TLR7/8/9 are responsible for nucleic acid recognition and they trigger proinflammatory responses through activation of NK-kappaB and Type I IFN production, making a bridge between the innate and the adaptative...

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Source

Identifiers

PMID: 22065095
DOI: 10.1177/0961203311425522

Genes

TLR7
TLR9
TLR8

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