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Article

Maspin is not required for embryonic development or tumour suppression

20 Jan 2014

Abstract excerpt

Maspin (SERPINB5) is accepted as an important tumour suppressor lost in many cancers. Consistent with a critical role in development or differentiation maspin knockout mice die during early embryogenesis, yet clinical data conflict on the prognostic utility of maspin expression. Here to reconcile these findings we made conditional knockout mice. Surprisingly, maspin knockout embryos develop into overtly normal...

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PMID: 24445777
DOI: 10.1038/ncomms4164

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