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Article

Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Jul 2014

Parnetti Lucilla, Chiasserini Davide, Persichetti Emanuele, Eusebi Paolo, Varghese Shiji, Qureshi Mohammad M, Dardis Andrea, Deganuto Marta, De Carlo Claudia, Castrioto Anna, Balducci Chiara, Paciotti Silvia, Tambasco Nicola, Bembi Bruno, Bonanni Laura, Onofrj Marco, Rossi Aroldo, Beccari Tommaso, El-Agnaf Omar, Calabresi Paolo

Abstract excerpt

To assess the discriminating power of multiple cerebrospinal fluid (CSF) biomarkers for Parkinson's disease (PD), we measured several proteins playing an important role in the disease pathogenesis. The activities of β-glucocerebrosidase and other lysosomal enzymes, together with total and oligomeric α-synuclein, and total and phosphorylated tau, were thus assessed in CSF of 71 PD patients and compared to 45...

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Identifiers

PMID: 24436092
DOI: 10.1002/mds.25772
PMCID: PMC4282452

Genes

GBA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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