Article
Cerebrospinal fluid β-glucocerebrosidase activity is reduced in parkinson's disease patients.
Movement disorders : official journal of the Movement Disorder Society - 1 Oct 2017
Parnetti Lucilla, Paciotti Silvia, Eusebi Paolo, Dardis Andrea, Zampieri Stefania, Chiasserini Davide, Tasegian Anna, Tambasco Nicola, Bembi Bruno, Calabresi Paolo, Beccari Tommaso
Abstract excerpt
BACKGROUND: Reduced β-glucocerebrosidase activity was observed in postmortem brains of both GBA1 mutation carrier and noncarrier Parkinson's disease patients, suggesting that lower β-glucocerebrosidase activity is a key feature in the pathogenesis of PD. The objectives of this study were to confirm whether there is reduced β-glucocerebrosidase activity in the CSF of GBA1 mutation carrier and noncarrier PD...
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