Article
Characterization of Brain Lysosomal Activities in GBA-Related and Sporadic Parkinson's Disease and Dementia with Lewy Bodies.
Molecular neurobiology - 1 Feb 2019
Moors Tim E, Paciotti Silvia, Ingrassia Angela, Quadri Marialuisa, Breedveld Guido, Tasegian Anna, Chiasserini Davide, Eusebi Paolo, Duran-Pacheco Gonzalo, Kremer Thomas, Calabresi Paolo, Bonifati Vincenzo, Parnetti Lucilla, Beccari Tommaso, van de Berg Wilma D J
Abstract excerpt
Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase), are the most common known genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). The present study aims to gain more insight into changes in lysosomal activity in different brain regions of sporadic PD and DLB patients, screened for GBA variants. Enzymatic activities of GCase, β-hexosaminidase,...
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