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Article

Host genetic variants of ABCB1 and IL15 influence treatment outcome in paediatric acute lymphoblastic leukaemia.

British journal of cancer - 18 Mar 2014

Lu Y, Kham S K Y, Ariffin H, Oei A M I, Lin H P, Tan A M, Quah T C, Yeoh A E J

Abstract excerpt

BACKGROUND: Host germline variations and their potential prognostic importance is an emerging area of interest in paediatric ALL. METHODS: We investigated the associations between 20 germline variations and various clinical end points in 463 children with ALL. RESULTS: After adjusting for known prognostic factors, variants in two genes were found to be independently associated with poorer EFS: ABCB1 T/T at either...

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Identifiers

PMID: 24434428
DOI: 10.1038/bjc.2014.7
PMCID: PMC3960629

Genes

ABCB1
EFS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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