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Article

Absence of GPR54 and TACR3 mutations in sporadic cases of idiopathic central precocious puberty.

Hormone research in paediatrics - 1 Jan 2014

Leka-Emiri Sofia, Louizou Eirini, Kambouris Marios, Chrousos George, De Roux Nicolas, Kanaka-Gantenbein Christina

Abstract excerpt

BACKGROUND/AIMS: Kisspeptin (KISS1)/GPR54 (KISSR) signaling complex and neurokinin B (NKB)/NKB receptor (TACR3) signaling have been proposed as an integral part of the network coordinating GnRH release. GPR54 (KISS1R) and TACR3 gene mutations have been described in cases of idiopathic hypogonadotrophic hypogonadism, while limited data exist on gain-of-function mutation in GPR54 (KISS1R) gene causing idiopathic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24434351
DOI: 10.1159/000356913

Genes

TACR3
KISS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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